Now, we are beginning to hear about vaccination against cocaine abuse (TA-CD vaccine), tobacco abuse (NicVAX) and many other diverse fields in which vaccines were not, usually, associated with. Recently, scientists suggested that we may not have to bother about medicating ourselves with antihypertensive drugs (drugs that lower blood pressure) for the control of blood pressure anymore. One or more shot of a vaccine directed against angiotensinII may in future, keep the B.P. under control. Thus, vaccination is effective against drug dependence as well as in the regulation of high blood pressure.
Angiotensin 2 is a potent vasoconstrictor, which is produced from angiotensinogen, when the enzyme Angiotensin Converting Enzyme (ACE) acts upon it (angiotensinogen). So far, scientists focused on:
- inhibiting ACEs (some ACE inhibitors are: Lisinopril, Ramipril, Captopril, Perindopril) blocking angiotensin receptors (Losartan, Irbesartan,Telmisartan)
- blocking endothelin receptors (Bosentan, a drug which is pretty effective in pulmonary hypertension. Endothelin being a potent vasoconstrictor raises blood pressure). ACEIs (ACE inhibitors) gave survival advantages, in addition to the inhibition of cardiac remodeling.
- Beta blockers (e.g. metoprolol, bisoprolol etc), Calcium channel blockers (amlodipine) and other drugs. But novel approaches are emerging.
As long as there is no autoimmune reaction, and the kidney is not burdened with immune complexes, the novel therapeutic approach is likely to succeed.
Last modified: July 13, 2009
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